As one has come to expect from Apple, accessibility is built right into the device out of the box. Of course, the Nano doesn’t have an external speaker, so you need to use the headphones that come with it. Also, setup has to be done by connecting to iTunes, since it doesn’t have wireless capabilities. You also need to turn on VoiceOver through the Universal Access options in iTunes, though you can set the triple click home option to work for VoiceOver on the iPod itself in the Accessibility settings area once you have the device synced through iTunes.
This is a great hands-on piece on using the iPod nano 7th-generation with VoiceOver. Check it out. It’ll make you want one.